Since I read around six books simultaneously from fiction to hardcore non-fiction-technical, I'd like to read just about anything. But the writers I do read, who are published by the major leaguers, all agree as to one thing: If people can't see your book on the shelf at B&N--you're not going to get a major publisher. Be glad if you get a legitimate publisher at all.
Vantage House publishers and their like will publish anything for your money, and offer you a lousy return. Be curious to learn who your publisher is. The latest copy of the Writer's Yearbook is one excellent source. Some publishers will accept unsolicited queries so even without an agent, you stand a good chance.To learn more about Bart, check out: http://bullittinn.wordpress.com/