Guest blogger Kellie Joanne Kamryn says “never give up.”
My first piece of advice for any writer would be not to give up. Rejections come in abundance sometimes, but keep learning your craft, keep networking, and keep researching which publishers might suit your work. For a couple of years, I submitted only to be rejected. I stopped submitting for a while just to get the feel for the industry and research what publishing houses might work well for me.
Use your instinct. Just because an agent or publishing house is a big name, if your instinct is telling you not to submit there, then listen to it even if you don't have a concrete "why" as to your feeling. Perhaps you're not ready. Maybe they just aren't a good fit. Talk to other writers about their publishing houses too. A good recommendation can go a long way on your search to being published.